Upper extremity complications are common following stroke and may be seriously debilitating. Regaining mobility in the upper extremities is often more difficult than in lower extremities, which can seriously impact the progress of rehabilitation. This chapter provides current information regarding upper extremity interventions. Topics include robotic devices for movement therapy, virtual reality technology, spasticity treatment, EMG/biofeedback, transcutaneous electrical nerve stimulation, functional electric stimulation, and hand edema treatment. Neurodevelopmental upper extremity therapy techniques are reviewed along with repetitive/task-specific training, sensorimotor interventions, hand splinting and constraint induced movement therapy.